教授 博士生导师 2001年毕业于北京大学生命科学学院 获理学学士学位 2006年毕业于北京大学生命科学学院 获理学博士学位 2006至2013年 在美国国立卫生研究院（NIH）酒精滥用与酒精中毒研究所（NIAAA）从事博士后研究工作
2013年3月加入中国科学技术大学生命科学学院。“万人计划”科技创新领军人才，科技部“中青年科技创新领军人才”，中国科学技术大学杰出研究校长奖，中科院优秀导师，唐立新优秀学者奖获得者，中国科学院脑科学与智能技术卓越创新中心青年骨干。长期从事神经化学、感知觉相关神经环路、离子通道病发病机制、小分子药物研发相关的神经科学研究，并取得以系列重要研究成果。研究成果发表在Cell, Nature Neuroscience, Nature Chemical Biology, Journal of Experimental Medicine, PNAS, Cell Reports，iScience，Journal of Neuroscience, Neuropharmacology, Journal of Biological Chemistry等国际学术期刊上。获得过多项国家级基金资助。
研究兴趣与方向：
1.探究感知觉的神经环路机制及其相关疾病，如癫痫、慢性痛、抑郁症、成瘾和耐受等，并开发相应的新型 治疗药物和治疗方法。
2.开发新型神经-化学技术，如单细胞质谱、单细胞器质谱、脑质谱成像等。
3.依托单细胞质谱和脑质谱成像技术，研究阿尔兹海默病、帕金森氏病等神经退行性疾病中小分子代谢组的变化及其分子机制，寻找相关的早期诊断标志物以及治疗方法。
4.探索配体门控离子通道的调控机制，如甘氨酸受体和伽马氨基丁酸。
代表性论文：
1. Hongying Zhu#; Ning Wang#; Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li; Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang*; Wei Xiong*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell, 173, 1716-1727 (2018)
2. Guichang Zou#, Xin Zuo#, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu and Wei Xiong*. Cannabinoids Rescue Cocaine-induced Seizure by Restoring Brain Glycine Receptor Dysfunction. Cell Reports, 30 (12), 4209-4219 (2020)
3. Hongying Zhu#, Guichang Zou#, Ning Wang#, Meihui Zhuang, Wei Xiong* & Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. PNAS, 114: 2586-2591 (2017)
4. Guichang Zou, Jing Xia, Qianqian Han, Dan Liu, and Wei Xiong*. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. The Journal of Biological Chemistry, 295: 138-145 (2020)
5. Xiaoqun Wang#; Yiwen Hou#; Zhuanghao Hou; Wei Xiong*; Guangming Huang*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization. Analytical Chemistry, 91(4): 2719~2726 (2019)
6. Chengyuan Liu, Keke Qi, Lei Yao, Ying Xiong, Xuan Zhang , Jianye Zang, Changlin Tian, Minggao Xu, Jiuzhong Yang , Zhenkun Lin , Yongmei Lv, Wei Xiong*, and Yang Pan*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Analytical Chemistry, 91(10): 6616-6623 (2019)
7. Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang and Wei Xiong*. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience, 19: 634-646 (2019)
8. Jieping Lu#*; Sijia Fan#; Guichang Zou; Yiwen Hou; Tao Pan; Weiwei Guo; Lei Yao; Feng Du; GE Homanics; Dan Liu; Li Zhang; Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology, 133: 224-232 (2018)
9. Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E. Homanics, John Peever, Kenner C. Rice, Ling-gang Wu, Hui-Lin Pan & Li Zhang. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nature Neuroscience, 17: 232-239 (2014)
10. Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology,7: 296-303(2011)
11. Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
12. Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
招生招聘：
实验室招聘分析化学、神经生物学或分子生物学等相关背景的co-PI、博士后和实验员，待遇从优。同时欢迎本科实习生和报考研究生。
联系方式：
电话：0551-63601736；邮箱：wxiong@ustc.edu.cn；
通讯地址：安徽省合肥市蜀山区中国科学技术大学西校区科技楼917
实验室网页： http://x-lab.ustc.edu.cn/
